After WWII ended, there were several well-attended reunions of the "Tuskegee Airmen" - the men and women who participated in the Tuskegee Experience by serving in the Army Air Corps Program at Tuskegee, Alabama or one of the units growing out of that program. In August 1972, the Airmen gathered in Detroit, Michigan and voted to establish a nation-wide organization with membership open to all supporters. They elected LtCol (Ret) John J. Suggs as "Commander" and authorized him to form committees and finalize the process. The organization was incorporated February 25, 1975 in the District of Columbia as a "veterans" organization. In 1978, an organizational structure was adopted which replaced the Commander with a National President and the Articles of Incorporation were amended to read: "Charitable and educational organization".

In 1988, the Detroit Chapter formed the Tuskegee Airmen National Historical Museum Board to oversee the museum at Historic Fort Wayne in Detroit , Michigan . This facility provides a secure location where the memorabilia of the Tuskegee Airmen’s invaluable contribution to our nation can be safely preserved and attractively displayed. The Museum is host to over 12,000 visitors each year, predominately school groups.

The present day mission of Tuskegee Airmen, Inc.® is to inspire young people to outstanding achievement and leadership in our democratic society through social and educational activities. To achieve this objective, the Airmen motivate, inspire and stimulate young people to study, sacrifice and attain self-sustaining status with marketable skills in the fields of aviation and aerospace. The officers, directors and board members of this federal tax-exempt organization serve without salary or fee.

The highlight of the year for Airmen is the opportunity to gather for the TAI National Convention. Tuskegee Airmen are acutely aware of the importance of staying in touch with each other and staying in touch with their heritage. Each year the convention site rotates between regions, with a chapter volunteering to serve as host.